By Dr. Mercola on February 12 2011

In this interview, Dr. Duane Graveline, a family doctor with 23 years experience and a former astronaut, discusses the health implications of cholesterol, statin drugs, and coenzyme Q10.

Dr. Graveline has an interesting background that makes him particularly suited to speak on the topic of statin drugs. He’s a medical doctor with 23 years of experience whose health was seriously damaged by a statin drug. His personal questions brought him out of retirement to investigate statins, which he’s been doing for the past 10 years.

As a former astronaut, he would get annual physicals at the Johnson Space Center in Houston. In 1999 his cholesterol hit 280 and he was given a prescription for Lipitor.

“When they suggested Lipitor (10 mg), I went along with it because I had no reason to be particularly worried about statin drugs,” he says. “I had used it a year or so before my retirement, but I wasn’t a big user.”

However, it quickly became apparent that something was seriously wrong.

“It was six weeks later when I experienced my first episode of what was later diagnosed as transient global amnesia,” Dr. Graveline says.

“This is an unusual form of amnesia wherein you immediately, without the slightest warning, are unable to formulate new memory and you can no longer communicate. Not because you cannot talk, but you can’t remember the last syllable that was spoken to you. So nothing you say is relevant anymore. In addition, you have a retrograde loss of memory, sometimes decades into the past.”

He “woke up” about six hours later in the office of a neurologist, who gave him the diagnosis: transient global amnesia. He quit taking the Lipitor despite the reassurances from his doctors that the drug was not of concern, and that it was just a coincidence.

He had no relapses during the remainder of the year, but his cholesterol was still around 280 at his next physical. He was again urged to take Lipitor, and he relented.

“I admit I was concerned, but I had talked to maybe 30 doctors and a few pharmacologists during the interval,” Dr. Graveline says. “They all said “statins don’t do that.” So I allowed myself to go back on statins but this time I took just 5 mg.

…[E]ight weeks later, I had my second, and my worst episode. In this one, I was a 13-year-old high school student for 12 hours… This is what convinced me, when I finally woke up, that something was wrong with the statin drugs. And yet, the doctors were, for years after that, still saying that this was just a remarkable coincidence.

This took me out of retirement and I’ve been actively involved in researching statin drugs ever since.”

Statin Drugs: Not Nearly as Safe as You’re Told

Dr. Graveline has since published a book about his discoveries called Lipitor: Thief of Memory.

“In trying to reach an explanation, I called Joe Graedon and asked him if he had ever heard of any unusual reactions associated with statins,” Dr. Graveline says of his initial investigations.

He was directed to the statin effects study by Beatrice Golomb in San Diego, California, and his story was also published in a syndicated newspaper column. Within weeks, the web site he had created received reports of 22 cases of transient global amnesia, along with hundreds of cases of cognitive damage. At present, over 2,000 cases of transient global amnesia associated with the use of statins have been reported to FDA’s MedWatch.

But cognitive problems are not the only harmful aspect of these drugs. Other serious adverse reactions include:
•Personality changes / mood disorders
•Muscle problems, polyneuropathy (nerve damage in the hands and feet), and rhabdomyolysis (a serious degenerative muscle tissue condition)
•Sexual dysfunction
•Immune suppression
•Pancreas or liver dysfunction, including a potential increase in liver enzymes
•Cataracts

According to Dr. Graveline, a form of Lou Gehrig’s disease or ALS may also be a side effect, although the US FDA is resistant to accept the link found by their Swedish counterpart, and has so far refused to issue a warning.

“The World Health Organization (WHO) reported on this in July 2007 when Ralph Edwards, who directs the Vigibase in Sweden (the equivalent of the US MedWatch), reported ALS-like conditions in statin users worldwide,” Dr. Graveline says.

He has since forwarded hundreds of cases to MedWatch, but the FDA still has not been moved to act, and doctors are therefore unaware of the connection between this deadly disease and statin use.

“[W]e have anecdotal evidence that if you stop the statin drug early enough, some of these cases regress. That’s why we thought it was important that FDA issue a warning, but they haven’t,” Dr. Graveline says.

Today, all of these adverse effects, including the cognitive problems Dr. Graveline warned about 10 years ago, are supported by published research. MedWatch has received about 80,000 reports of adverse events related to statin drugs, and remember, only an estimated one to 10 percent of side effects are ever reported, so the true scope of statins’ adverse effects are still greatly underestimated.

For a more in-depth explanation of how statins damage your mitochondria and DNA, resulting in a variety of health problems, please listen to the interview in its entirety or read through the transcript as he discusses far more than I can include here.

How Statins Harm Your Brain Function

As is often the case with pharmaceutical drugs, the side effects end up teaching us new things about how the human body works. When statins first hit the market, conventional medicine was unaware of the importance of cholesterol for proper brain function. Now, researchers believe that statins’ adverse effects on cognition are due to cholesterol insufficiency.

Research also began to emerge in 2001 showing the importance of cholesterol in the formation of memories.

“Then we have… dolichols,” Dr. Graveline says. “[W]hen a statin is used, it blocks the mevalonate pathway to get at cholesterol inhibition. It works very beautifully. But in so doing, it blocks CoQ10, dolichols, as well as other major biochemicals…

[D]olichol is one that most doctors have never even heard of before, but it just so happens that dolichols are almost as important as CoQ10 and cholesterol in cell processing.”

In fact, dolichols are vital to a number of cellular processes, including:
•Glycoprotein synthesis
•Cell identification
•Cell communication
•Immunodefense
•Neurohormone formation

Dr. Graveline goes on to explain that dolichols influence all the hormones involved with your mental condition, including your emotions and moods. And if you do not have sufficient dolichol, your entire process of neurohormone production will be altered—with potentially devastating results.

“There are thousands of reports of aggressiveness and hostility, increased sensitivity, paranoia, depression and homicidal ideation,” Dr. Graveline says.

There are also numerous reports of suicide.

“This whole range of what I call personality- or emotion and behavioral responses have to do with the dolichol deficiency brought on by the mevalonate blockade,” Dr. Graveline explains.

“It’s not just something that occurs in an occasional person… You know we’re all the same and yet we’re all different… You give one medicine to 10 people and if you’re really lucky, in six of them it will do what it’s supposed to do. That’s the way it is with this. I expect there are some people that won’t get any effects of dolichol suppression because they have alternative pathways. The same thing probably holds for CoQ10.”

That said, it’s important to realize that your brain also requires cholesterol in order for memory formation to function normally. In essence, statins suppress a number of vital elements for proper brain functioning, including cholesterol, antioxidants and co-factors like CoQ10, and dolichol.

At the same time, statins also create mitochondrial DNA and cellular damage, including in your brain.

Your brain uses glial cells as factories for producing its own cholesterol on demand. Unfortunately, glial cells are affected by statins in the same way as your liver cells, or any other cell in our body. So if you take a statin, you’re also harming your glial cells and when they cease to function normally, that on-demand cholesterol capability also ceases and your brain can no longer function properly.

The Importance of CoQ10 (Ubiquinol) if You’re Over 40,

It’s now clear that if you take statin drugs without taking CoQ10, your health is at serious risk as statin drugs deplete your body of this essential co-enzyme. As your body gets more and more depleted of CoQ10, you may suffer from fatigue, muscle weakness and soreness, and eventually heart failure. Coenzyme Q10 is also very important in the process of neutralizing free radicals.

So when your CoQ10 is depleted, you enter a vicious cycle of increased free radicals, loss of cellular energy, and damaged mitochondrial DNA.

Unfortunately, the majority of people who take statins are unaware of their need for CoQ10, and physicians rarely advise their patients to take this supplement along with their statin—at least in the United States. It’s also important to supplement right from the start. According to Dr. Graveline, once the mitochondrial damage and mutations are formed they cannot be reversed—no matter how much CoQ10 you take.

So early intervention is key. (Dr. Graveline goes into further detail of how CoQ10 offers protection against mitochondrial DNA damage in this interview, so for more information, please listen to it in its entirety.)If you decide to take a CoQ10 supplement and are over the age of 40, it’s important to choose the reduced version, called ubiquinol.

Ubiquinol is a FAR more effective form—I personally take 1-3 a day as it has far-ranging health benefits. Dr. Graveline concurs with this recommendation.

As for dosage, Dr. Graveline makes the following recommendation:
•If you have symptoms of statin damage such as muscle pain, take anywhere from 200 to 500 mg
•If you just want to use it preventively, 200 mg or less should be sufficient

There’s also evidence that CoQ10/ubiquinol is beneficial for Parkinson’s disease and Alzheimer’s disease, and even cancer, and that large doses may be justified in those cases as well.

In addition, CoQ10 is believed to play an important role in preventing premature aging in general by preventing telomere shortening, which can slow or potentially even reverse the aging process. This is just one of the additional benefits of CoQ10, and one of the reasons why I take ubiquinol daily even though I’ve never been on a statin drug.

There are no reported side effects of CoQ10 supplementation, and neither I nor Dr. Graveline have ever heard of anyone overdosing on it. The only drawback is cost.

However, if you’re taking ubiquinol, here’s some cost-saving information for you.

Certified reduced ubiquinol is only manufactured by one company in the entire world, a Japanese company called Kaneca. They own the patent. So, as long as it’s certified ubiquinol, you can buy the cheapest brand you can find, because they’re all the same.

Other Valuable Antioxidants for Optimal Health—Especially if You’re Taking a Statin

CoQ10, or preferably the reduced version, ubiquinol, is at the top of the list of important supplements when you’re taking a statin drug. But there are also other antioxidants and nutrients that can be helpful. For example, selenium is also seriously inhibited by statin drugs, and selenium, along with magnesium, are commonly involved as co-factors in a variety of biological functions.

Other important nutrients include:
•Vitamin C
•Vitamin D
•Vitamin E—An emerging form of vitamin E called tocotrienol is 50 times more powerful than tocopherol, which has been used for the past 60 years. It also helps produce cholesterol and has other biochemical advantages
•Alpha-lipoic acid
•L-carnitine—which helps metabolize fats properly. Since about 70 percent of your muscles’ energy comes from fats, it’s important to have the ability to metabolize them. INSERT LINE BREAK According to Dr. Graveline: “If you take L-carnitine and find that you suddenly feel much better, then you’ve just proven you need it for the rest of your life because you’re one of those people who have a dysfunction in this capability; you don’t have the means to properly burn fats at our muscle level… naturally you would then get weak when exercising. So it’s useful for making a diagnosis. If nothing happens after three months of a good dose, then I would say you can forget about L-carnitine.”

The Sad Truth: Even Your Doctor has Been Mislead About Cholesterol

That said, aside from taking CoQ10 if you’re on a statin, your diet really should be your primary source of nutrients. (For vitamin D, you’d ideally get it from sun exposure.) Supplements are just that; supplemental to an otherwise healthy diet.

“I think that when you have a statin associated muscle or nerve or even brain dysfunction, this is where you’ve got to go because that’s where the trouble is,” Dr. Graveline agrees.

“If it’s cholesterol inhibition, you just eat more eggs… I can’t believe I went 17 years and never ate an egg. I can’t believe how gullible I was. I was this young medical doctor; I marched to that band of the cholesterol-causation people… I did everything I was supposed to do, and it was all wrong. I can’t believe that I was led astray, maybe for 25 years of my practice! It’s so bad to have to look back and realize you’ve been treating cardiovascular disease erroneously because you were doing what you were asked to do.The sad truth is that cholesterol, our supposed enemy for 35 years, has nothing to do with cardiovascular disease. it is the most important biochemical in your body.

… We all listened to what amounts to brainwashing. The brainwashing that we got from 1955 on, to just recently… They have liberalized the diet stuff recently though, so people are back to eating eggs and drinking whole milk and eating butter. I went around recommending margarine for so long, and margarine is what’s causing disease—butter is what’s helping to cure it. It’s incredible!”

This is true for the majority of our conventional medical professionals. They simply do not know better… which is all the more reason to arm yourself with the information you need to take control of your own health. Shunning statin drugs and addressing your lifestyle is the way to go if you have high cholesterol. For more information, please see my statin index page which includes a plethora of free guidance and clear advice.

More Information

Dr. Graveline covers a lot of information in this interview, so I highly recommend you listen to the entire interview, or read through the transcript. You can also find more information on his web site: www.SpaceDoc.net .

Dr. Graveline’s site serves both as a tool for reporting statin complications, and a database of adverse effects, which are then forwarded to the appropriate agencies.

Dr. Duane Graveline’s Video on Cholesterol, Q10 and Statins

http://articles.mercola.com/sites/articles/archive/2011/02/12/dr-duane-graveline-on-cholesterol-and-coq10.aspx

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Medication corporations make billions setting statin drugs to people with high cholesterol. Proof exists that statins lower cholesterol amounts. Now statins are branded as a drug that reduces the potential for heart attacks. However, a study of statin studies implies that drug corporations are fudging the information to support their marketing campaigns. It’s no surprise that corporations which take out installment loans to create merchandise skew their findings. Resource for this article – Review questions data supporting statins to prevent heart disease by MoneyBlogNewz.

Statin sales in billions for medication companies

There were $35 billion statin medication sales from medication corporations. This is what pharmaceutical consulting firm IMS explained. About $13.3 billion was sold last year of Lipitor which is a Pfizer statin drug. In fact, it was the number one selling medication within the world. In order to lower high cholesterol, several will take Lipitor. Millions will do this every year. AstraZeneca, in a race to catch up with Pfizer, has convinced the Food and Medication Administration to approve its statin Crestor as a drug for healthful individuals who want to prevent cardiovascular disease. You will find many people at a very low risk for heart disease though. These individuals don’t have several benefits which were discovered by a British research group who did a study on it.

Benefit of drug corporations happens with skewed statin drug studies

The Cochrane Database of Systematic Reviews did a study of 14 different statin drugs. There isn’t any evidence that claims statins needs to be taken by individuals with low risk of heart disease. There isn’t any evidence at all that it helps. There isn’t any evidence to show that a person unlikely to get a heart attack advantages from taking statins. There is evidence that it helps those who have already had a heart attack prevent it from occurring again though. There were relationships between medication companies and scientists employed too, according to Cochrane scientists. The outcomes were chosen by the scientists due to the data chosen to be used. Pharmaceutical companies argue that it is all in how “low risk” is defined and that statin drugs save money in the health care system because they’re cheaper than surgery and other forms of treatment.

Advantages aren’t enough to over-shadow statin unwanted effects

Statin drugs help people genetically predisposed to high cholesterol protect their health. However, statin advantages come with unwanted effects such as memory loss and degeneration of muscle tissue, as well as liver and kidney problems. Statin drugs are accessible by prescription and sold over the counter. Physicians commenting on the Cochrane statin review suggested that people see their doctor to determine their risk level for heart disease before taking statins. It is bad to take it if there is a very low risk level. This means you will experience negative effects without a benefit.

Citations

ABC News : abcnews.go.com/Health/researchers-question-statins-prevent-heart-disease/story?id=12638427

Red Orbit : redorbit.com/news/health/1981524/questionable_benefits_of_statins_for_lowrisk_patients/

The Telegraph : telegraph.co.uk/health/healthnews/8267876/Statins-the-drug-firms-goldmine.html

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Postage prices are now even better with multiple orders

goto  http://advancedq10.com/where-to-buy-coenzyme-q10/

click through to the shopping cart and add items to bag …  then enter your postcode and you’ll see the new prices.

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While many studies have shown benefits in lowering cholesterol in patients with previous coronary events, it is questionable as to whether statin-induced lowering of cholesterol is beneficial for high-risk patients with no history of previous heart disease. Indeed, there is data to suggest otherwise, as evidenced in this meta-analysis published this year (2010). (1)

We’ll leave the statin drug controversy as a topic for another article, and focus on the critical information statin drug users need to know. Statin drugs are associated with a disturbing long list of potentially deadly or disabling side effects, many of which likely stem from the depletion within the body of a critical nutrient known as Coenzyme Q-10 (CoQ10). (2)

…….  Follow the link to read full article by Marcus Gitterle, MD

Statin Drugs and Coenzyme Q10 Deficiency | Natural Health Informer.com …
http://www.naturalhealthinformer.com/statin-drugs-and-coenzyme-q10-deficiency.html

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Cerebrospinal Fluid (CSF) Concentration of Coenzyme Q10 in Clinical Practice

 There is significant interest in coenzyme Q10 (CoQ10) as a potential treatment for neurodegenerative diseases and in its promise as a neuroprotectant. Experimental studies indicate that CoQ10 can protect against brain disorders by inhibiting neuronal damage.

follow the link to study findings demonstrating csv levels of coq10 in humans http://www.bentham.org/open/tosnutraj/articles/V002/13TONUTRAJ.pdf
 

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Coenzyme Q10 іѕ a top cardio-friendly nutrient. Yουr heart hаѕ very high energy requirements аnԁ never gets tο take аnу time οff. Q10 іѕ required fοr thе proper production οf energy аt аn optimal rate, around уουr body аnԁ specifically fοr уουr heart. If уου lack іt, уου wіƖƖ bе more tired аnԁ уου wіƖƖ mаkе free radicals instead οf energy. If уου lack Q10 within уουr heart іt wіƖƖ speed up thе aging process аnԁ weaken уουr heart.

Q10 аƖѕο operates аѕ a direct antioxidant іn cell membranes, meaning thаt іt іѕ highly protective tο уουr overall circulatory system, having a direct benefit tο support healthy blood pressure. It аƖѕο acts аѕ аn antioxidant team player, helping vitamins E аnԁ C maintain thеіr antioxidant roles whісh provides additional synergistic cardiovascular protection.

It іѕ very clear frοm thе literature thаt statins interfere wіth thе natural production οf Q10, whісh іѕ evidenced bу lower blood levels οf Q10 іn patients taking statins. It hаѕ bееn known fοr over a decade thаt statin drugs reduce Q10 levels аѕ much аѕ 25% аnԁ thаt 100 mg οf Q10 іѕ enough tο offset a relatively low dose οf statins (20 mg οf Zocor.)

Sіnсе Q10 іѕ essential fοr energy production within cells, energy іѕ reduced. Thіѕ results іn fatigue, mаkеѕ іt more difficult tο exercise, аnԁ іѕ раrt οf thе reason fοr muscle aches аnԁ pains іn ѕοmе statin-taking patients. Thе interference wіth cell energy production results іn аn increased production οf lactic acid, whісh contributes tο muscle aches. In patients wіth muscle pain associated wіth statin υѕе a double blind study ѕhοwеԁ thаt 100 mg per day οf Q10 reduced pain bу 40%.

Thе medical profession ԁοеѕ nοt endorse thе widespread υѕе οf Q10 wіth аƖƖ statin takers bесаυѕе іt саnnοt bе proven thаt a lack οf Q10 іѕ thе cause οf аƖƖ statin-related muscle pain. Thіѕ wіƖƖ never bе proven, bесаυѕе statins cause muscle pain іn multiple ways. Statins turn οn gene signals thаt ԁаmаɡе muscles іn a percentage οf patients, independent οf Q10. It seems tο elude thе logic οf doctors thаt іf a drug causes a depletion οf a nutrient thеn thе nutrient ѕhουƖԁ bе consumed tο mаkе up fοr thе deficiency.

One study ѕhοwеԁ thаt thе adverse side effects іn fifty consecutive patients wаѕ ѕο bаԁ (muscle pain, fatigue, difficulty breathing, memory loss, аnԁ nerve problems) thаt thеу wеrе аƖƖ taken οf statins аnԁ рυt οn 240 mg a day οf Q10 tο recover. Aftеr a year thе ɡrеаt majority οf adverse side effects hаԁ bееn cleared up. It іѕ pretty obvious thаt thе side effects οf statins аrе under-reported.

One οf thе serious side effects οf statins іѕ actual ԁаmаɡе tο thе heart resulting іn thе condition known аѕ cardiomyopathy. Thе severe side effects οf statins іn people over 70 аrе ѕο bаԁ thаt thеіr υѕе саnnοt bе justified. Indeed, thеrе аrе now over 450,000 nеw cases οf heart failure per year іn thіѕ older group οf Americans, аnԁ іt іѕ ƖіkеƖу thаt statins аrе a cause οf thіѕ dramatically expanding health problem.

An animal study helps shed light οn whу ѕοmе people mау ɡеt cardiomyopathy аnԁ others don’t. Animals lacking іn friendly nitric oxide (eNOS), whісh manifests аѕ high blood pressure, wеrе more аt risk οf cardiovascular toxicity frοm statins. Thіѕ іѕ іntеrеѕtіnɡ bесаυѕе Q10 іѕ аƖѕο аn antioxidant аnԁ a lack οf eNOS implies thаt antioxidants іn thе circulatory system аrе already low. AƖѕο, аѕ fatigue іn аnу individual increases thеn free radicals within cells increase, something thаt Q10 helps reduce.

Thus, іf Q10 levels аrе driven down even further іt mіɡht cause major problems. Thіѕ means thе worse thе health a person іѕ іn, thе greater thе need tο bе sure tο take Q10, especially іf οn a statin. Thе combination οf high blood pressure аnԁ type II diabetes wουƖԁ flag аn individual already seriously lacking eNOS activity. Indeed, a brаnԁ nеw study shows thаt 200 mg οf Q10 per day improves circulation іn type II diabetic patients taking statins.

On thе οthеr side οf thе coin, taking Q10 іѕ helpful іn restoring cellular energy production within уουr heart аnԁ around уουr body. It аƖѕο helps reduce free radical production іn уουr general circulation, improving thе status οf friendly nitric oxide tο relax уουr vascular system – thereby supporting healthy blood pressure.

Thеѕе positive influences οf Q10 fοr cardiovascular health extend far beyond thе notion οf simply correcting a deficiency. It іѕ more οf аn anti-aging concept fοr уουr cardiovascular system.

Thе fact thаt fοr those taking statins thеіr Q10 іѕ lowered аѕ аn adverse side effect іѕ a very serious health issue. Thіѕ іѕ especially trυе fοr older Americans οr fοr anyone whο hаѕ a more advanced situation οf poor health, such аѕ type II diabetes аnԁ high blood pressure.

Unfortunately, thеrе аrе millions οf Americans being given statins whο аrе іn thіѕ high risk health category wherein a lack οf Q10 сουƖԁ aggravate already lacking antioxidant аnԁ energy systems, thus mаkіnɡ thеіr heart health worse. It іѕ shocking thаt thе rate οf heart failure іn those over thе age οf 65 hаѕ doubled over thе past two decades іn direct proportion tο thе increase οf statin υѕе – wіth over 450,000 extra cases οf heart failure per year.

Thіѕ nеw finding οn heart failure wаѕ reported fοr thе very first time аt last fall’s yearly meeting οf thе American Heart Association. It received very ƖіttƖе press, whіƖе thе media wаѕ instead fed another round οf faulty vitamin E data – аn ongoing attempt bу thе AHA tο ɡеt consumers tο ѕtοр taking vitamins аnԁ јυѕt take drugs.

It іѕ nοt easy tο sweep 450,000 cases οf serious injury under thе rug. I seem tο bе thе οnƖу one, even іn thе alternative health industry, whο іѕ pointing out thіѕ glaring problem. If уου аrе taking a statin іt іѕ prudent tο consume a dose οf Q10 ranging frοm 100 mg – 300 mg a day. Higher doses wουƖԁ bе warranted fοr those іn poorer health.

Anԁ fοr anyone, keep іn mind thаt CoQ10 іѕ a top cardio-friendly nutrient thаt саn hеƖр keep уου energized, уουr heart hарру, аnԁ уουr circulation flowing along іn a less stressed condition.

Byron J. Richards, Founder/Director οf Wellness Resources, Inc., іѕ a Board-Certified Clinical Nutritionist аnԁ a world renowned natural health expert.

article from articlesbase.com

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Seventeen years spent testing about 100 different Coenzyme Q10 (Ubiquinone, Ubidecaronene) formulations, attempting to improve absorption, delivery and efficiency of Coenzyme Q10 into the aerobic energy systems within human cells (mitochondria) has been my overwhelming “passion of life.”

Good fermented (natural) CoQ10 powder, along with careful laboratory handling should in dry capsule form deliver immediate (one minute) results in short- term tested efficiency. It should also give on going subtle health improvements year after year. This fact is known to me because one has documented consistent personal physical improvements in endurance and strength since including quality produced Coenzyme Q10 in my diet over the last 11 years, a complete change from the downward spiralling direction previously.
I’ve been involved personally with approximately 30,000 aerobic human efficiency tests on the subject of Coenzyme Q10 alone in the last 17 years entailing a broad spectrum of 91 different worldwide brands of CoQ10 using them as a comparison standard with our own locally (Australian) produced product. Some of these brands were tested 40 times to ascertain accuracy.

Facts that emerged during testing showed that soft gel, oil-based delivery CoQ10 formulations do exhibit increased blood plasma levels of CoQ10. However, it also showed high urine excretion rates of CoQ10! The CoQ10 delivery system that we use (phosphate-based) does not show high levels of CoQ10 excretion in urine even after massive doses are administered.
The system we use is far superior because it (CoQ10) is absorbed within seconds into surrounding arteries and muscles. It does not keep circulating in the blood, and to kidneys which automatically recognize the fact that it (CoQ10) is far above normal levels and is therefore excreted in the urine.

Coenzyme Q10 belongs, stores and is used by cellular mitochondria (aerobic system of cells). The quicker it is delivered to mitochondrial sites. the less is lost. and increased efficiency is gained.

We have tested 26 soft gel oil-based delivery CoQl0 with unbiased arbitrators overseeing testing procedures. Most of these soft get oil-based delivery preparations did produce some varying physical improvement efficiencies. The best was an American life extension formula which consistently gave 30% increase in efficiency only, according to milligrams of CoQ10 used compared with our local (Australian) product over a week long test. Some brands delivered zero efficiency readings even when subjects were given 225 – 450 milligrams of CoQ10 per day.

Modern pharmacology at this point in time worldwide demands blood plasma level of CoQ10 as evidence of cellular delivery. But in our experience, oils and fats drastically inhibit the amount of CoQ10 that can be absorbed through mitochondrial membranes where it is essentially used for efficient aerobic energy production. The fact is evident by treadmill and ergometer testing in human subjects conducted by myself in the presence of impartial judges. During the last 17 years, modern medicine can detect most essential nutrients in our blood plasma and generally that is a guide indicating cellular absorption of nutrients. But this is not always the truth.

There is only one real test that is foolproof in terms of body cell nutrient absorption and consequent physical improvements. This occurs when subjects are subjected to work-rate, heart-rate evaluations under physical load. With top quality CoQ10. 98% of people will show increased efficiencies under workload once CoQ10 is administered. The remaining 2% will generally respond within one week. Never have I recorded one case history with any subject using our CoQ10 where there has been no improvement given time. This statement is made with the aid of 30,000 separate stress tests concerning CoQ10 research.
Unfortunately, modern medicine has not yet managed to see or understand exactly what occurs within the mitochondria in respect to behaviour of the atoms of 84 elements that we use in our cells to create energy in the quest for survival.

Even our best microscopes would have to improve their magnification capacity by some 15 times to see an atom of hydrogen at work in the mitochondria.
The movement of hydrogen and oxygen atoms within the mitochondria is the major factor contributing to low toxic aerobic energy production necessary for health and survival.

Good quality CoQ10 contains a massive molecular structure of active hydrogen. It is my humble learning experience that the hype surrounding soft gel, oil-based delivery of CoQ10 does not stand up when faced with the human physical testing evidence with either short term or long term in terms of CoQ10 potentials. If it did, I would use oil-based delivery formulae.

It is yet another case of “Let The Buyer Beware!”

The quality of Coenzyme Q 10 varies greatly from supplier to supplier so select carefully.

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taken from an article on ehow.com

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